Efficacy of 1-Kestose Supplementation in Patients with Pancreatic Ductal Adenocarcinoma: A Randomized Controlled Pilot Study.
Kazunori NakaokaEizaburo OhnoKento KuramitsuTeiji KuzuyaKohei FunasakaTakumi TochioTadashi FujiiHideaki TakahashiNobuhiro KondoRyoji MiyaharaSenju HashimotoYoshiki HirookaPublished in: Nutrients (2024)
Less than half of all patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) respond to chemotherapy, and the prognosis of PDAC is poor, which may be mediated by the gut microbiota. We investigated the clinical improvement effects of 1-kestose, a fructooligosaccharide, on PDAC chemotherapy in this single-center, randomized, controlled pilot trial conducted at Fujita Health University Hospital, which enrolled patients with PDAC. The trial included 1-kestose administration and non-administration groups. The 1-kestose group received 9 g of 1-kestose daily for 12 weeks, and their blood markers, imaging studies, physical findings, and gut microbiota were evaluated. In the 1-kestose administration group, the cancer marker CA19-9 significantly decreased, and there was a reduction in the neutrophil-to-lymphocyte ratio (NLR). There was also suppression of the reduction of albumin levels and of an increase in C-reactive protein. Additionally, Escherichia coli , which typically increases in PDAC, significantly decreased in the 1-kestose group. Thus, 1-kestose altered the gut microbiota and improved the prognostic factors for PDAC. Large-scale, long-term trials of 1-kestose interventions for PDAC are thus warranted to improve the prognosis of PDAC.
Keyphrases
- prognostic factors
- escherichia coli
- physical activity
- public health
- end stage renal disease
- healthcare
- high resolution
- mental health
- newly diagnosed
- ejection fraction
- squamous cell carcinoma
- randomized controlled trial
- locally advanced
- chronic kidney disease
- clinical trial
- phase ii
- study protocol
- atomic force microscopy
- health information
- squamous cell
- staphylococcus aureus
- social media
- single molecule
- protein kinase
- candida albicans