Silencing SPP1 in M2 macrophages inhibits the progression of castration-resistant prostate cancer via the MMP9/TGFβ1 axis.

Saipeng ChenBingqian DengFuhan ZhaoHang YouYouxin LiuLanglang XieGuojing SongZhansong ZhouGang HuangWenhao Shen

Published in: Translational andrology and urology (2024)

We have found that the high expression of SPP1 in M2 macrophages promotes the progression of CRPC through cell-cell interactions. These findings can contribute to the development of novel therapeutic approaches for combating this deadly disease.

Keyphrases

single cell
cell therapy
poor prognosis
stem cells
epithelial mesenchymal transition
mesenchymal stem cells
binding protein
signaling pathway
genetic diversity