In vivo visualisation of different modes of action of biological DMARDs inhibiting osteoclastic bone resorption.

Yoshinobu MatsuuraJunichi KikutaYuika KishiTetsuo HasegawaDaisuke OkuzakiToru HiranoMasafumi MinoshimaKazuya KikuchiAtsushi KumanogohMasaru Ishii

Published in: Annals of the rheumatic diseases (2018)

Intravital imaging revealed that various biological DMARDs acted at specific therapeutic time points during osteoclastic bone destruction, with different efficacies. These results enable us to grasp the real modes of action of drugs, optimising the usage of drug regimens.

Keyphrases

bone mineral density
bone loss
soft tissue
high resolution
rheumatoid arthritis patients
bone regeneration
postmenopausal women
single cell
drug induced
emergency department
systemic lupus erythematosus
mass spectrometry
fluorescence imaging
electronic health record