Spermatogonial quantity in prepubertal boys undergoing fertility preservation is comparable between haematological and non-haematological cancers.
Prathima TholetiSindhura L Koulmane LaxminarayanaVani R LakshmiVasudeva K BhatVijay Kumar PShubhashree UppangalaGuruprasad KalthurNorah SpearsSatish Kumar AdigaPublished in: Human fertility (Cambridge, England) (2024)
Fertility restoration potential of immature testicular tissue (ITT) depends on the number of spermatogonial cells in the retrieved tissue prior to cryopreservation in oncofertility programme. There are limited data on the association between type of malignancy and testicular germ cell population. Hence, this study is aimed to investigate the spermatogonial and Sertoli cell population in ITT retrieved from 14 pre-pubertal boys who opted for fertility preservation. Histopathological and immunochemical analysis of seminiferous tubules from haematological ( N = 7) and non-haematological ( N = 7) malignant patients revealed 3.43 ± 2.92 and 1.71 ± 1.81 spermatogonia per tubular cross section (S/T), respectively. The Sertoli cell number was comparable between haematological and non-haematological group (18.42 ± 3.78 and 22.03 ± 10.43). Spermatogonial quantity in ITT did not vary significantly between haematological and non-haematological cancers. This observation, though preliminary, would contribute to the limited literature on paediatric male oncofertility.
Keyphrases
- germ cell
- end stage renal disease
- cell therapy
- randomized controlled trial
- intensive care unit
- stem cells
- chronic kidney disease
- ejection fraction
- childhood cancer
- machine learning
- clinical trial
- risk assessment
- electronic health record
- young adults
- deep learning
- prognostic factors
- patient reported outcomes
- human health
- colorectal cancer screening