A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression.

Hui Deng Cindy Lin Laura Garcia-Gerique Shuyu Fu Zachary Cruz Erin E Bonner Matthew Rosenwasser Sridharan Rajagopal M Naveen Sadhu Chandru Gajendran Mohd Zainuddin Ramachandraiah Gosu Dhanalakshmi Sivanandhan Miriam A Shelef Brian Nam Dan T Vogl Dmitry I Gabrilovich Yulia Nefedova

Published in: Cancer research (2022)

PAD4 regulates tumor progression by promoting neutrophil migration and can be targeted with a small molecule inhibitor to suppress tumor growth and metastasis and increase efficacy of immune checkpoint blockade therapy.

Keyphrases

small molecule
poor prognosis
cancer therapy
stem cells
drug delivery