A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor.
Akira InoueLaura J JankeBrian L GudenasHongjian JinYiping FanJoshua ParéMichael R ClayPaul A NorthcottAngela C HirbeXinwei CaoPublished in: Neuro-oncology advances (2021)
The NP-Plp model recapitulates human MPNST genetically, histologically, and molecularly.