Intrathecal immunoglobulins and neurofilament light after autologous haematopoietic stem cell transplantation for multiple sclerosis.
Diane LarssonTorbjörn ÅkerfeldtKristina CarlsonJoachim BurmanPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
Intrathecal immunoglobulin production and NFL were lower after treatment with aHSCT, decreased over time and were normalised in a significant portion of patients. This challenges the notion that OCB are unaffected by therapeutic intervention in MS.
Keyphrases
- stem cell transplantation
- multiple sclerosis
- end stage renal disease
- high dose
- newly diagnosed
- randomized controlled trial
- chronic kidney disease
- ejection fraction
- mass spectrometry
- prognostic factors
- peritoneal dialysis
- cerebrospinal fluid
- stem cells
- mesenchymal stem cells
- cell therapy
- patient reported
- platelet rich plasma