Industrial Trans Fatty Acids Stimulate SREBP2-Mediated Cholesterogenesis and Promote Non-Alcoholic Fatty Liver Disease.

Antwi-Boasiako OtengAnke LoreggerMichel van WeeghelNoam ZelcerSander Kersten

Published in: Molecular nutrition & food research (2019)

Elaidate induces cholesterogenesis in vitro by activating the SCAP-SREBP2 axis, likely by lowering intracellular free cholesterol and attenuating cholesterol-dependent repression of SCAP. This pathway potentially underlies the increase in liver cholesterol and NAFLD by industrial trans fatty acids.

Keyphrases

fatty acid
low density lipoprotein
heavy metals
wastewater treatment
signaling pathway
risk assessment
reactive oxygen species