Macrophage Migration Inhibitory Factor Is a Molecular Determinant of the Anti-EGFR Monoclonal Antibody Cetuximab Resistance in Human Colorectal Cancer Cells.
Rosita RussoNunzia MatroneValentina BelliDavide CiardielloMariangela VallettaSabrina EspositoPaolo Vincenzo PedoneFortunato CiardielloTeresa TroianiAngela NebbiosoPublished in: Cancers (2019)
Collectively, our results suggest the association of MIF signaling and its dysregulation to cetuximab drug resistance, paving the way to the development of personalized combination therapies targeting the MIF axis.
Keyphrases
- monoclonal antibody
- metastatic colorectal cancer
- endothelial cells
- small cell lung cancer
- locally advanced
- wild type
- epidermal growth factor receptor
- adipose tissue
- induced pluripotent stem cells
- tyrosine kinase
- pluripotent stem cells
- cancer therapy
- squamous cell carcinoma
- radiation therapy
- single molecule
- drug delivery
- rectal cancer