[Early predictive biomarkers of posttraumatic epilepsy].

K K Kryukova E V Alexandrova Olga N Voskresenskaya Anatol BraginV V PodlepichE Yu Sokolova E M Troshina Andrey OshorovA A Potapov

Published in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2021)

Traumatic brain injury (TBI) affects about 50 million people in the world every year. Posttraumatic epilepsy (PTE) is a significant complication of TBI of any severity. PTE occurs in 20% of patients with TBI. Treatment of patients with PTE is particularly difficult due to obvious tendency towards drug resistance. Currently, there are no validated predictive biomarkers for PTE. Development of a system of validated predictive markers would improve PTE prediction quality and therapeutic approach for these patients. This review is devoted to the current data on the most perspective predictive biomarkers of PTE for clinical practice.

Keyphrases

traumatic brain injury
severe traumatic brain injury
clinical practice
end stage renal disease
ejection fraction
newly diagnosed
mild traumatic brain injury
prognostic factors
machine learning
replacement therapy
data analysis