CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells.
Mai KhaledAmr S MoustafaNashwa El-KhazragyMaha Imam AhmedMarwa Ali Abd ElkhalekEman M El SalahyPublished in: PloS one (2021)
CRISPR-cas9-mediated knock-out of VPREB1 gene is effective for inhibiting the proliferation of primary myeloma cells. This would provide a basis for a promising therapeutic strategy for patients with multiple myeloma.