The Oncogenic Roles of PTTG1 and PTTG2 Genes and Pseudogene PTTG3P in Head and Neck Squamous Cell Carcinomas.

Inga GrzechowiakJustyna GraśDominika SzymańskaMartyna BiernackaKacper GuglasPaulina PoterAndrzej Adam MackiewiczTomasz Kolenda

Published in: Diagnostics (Basel, Switzerland) (2020)

PTTG3P and PTTG2 can be used as a prognostic biomarker in head and neck squamous cell carcinomas diagnostics. Moreover, patients with high expressions of PTTG3P, PTTG1 or PTTG2 have worse outcomes due to upregulation of oncogenic pathways and more aggressive phenotypes.

Keyphrases

squamous cell
transcription factor
type diabetes
high grade
poor prognosis
genome wide
signaling pathway
gene expression
metabolic syndrome
dna methylation
adipose tissue
insulin resistance
long non coding rna