Stratifying management of rheumatic disease for pregnancy and breastfeeding.
Ian GilesChee-Seng YeeCaroline GordonPublished in: Nature reviews. Rheumatology (2019)
The management of inflammatory rheumatic diseases during pregnancy and breastfeeding has undergone considerable change in the past few years. Modern therapeutics, including biologic and targeted synthetic DMARDs, have enabled substantial improvements in the control of rheumatic diseases, resulting in more patients with severe disease considering pregnancy. Therefore, management of disease for these patients needs to be discussed with clinicians before, during and after pregnancy and patients need to know what complications they might experience before they become pregnant. This Review summarizes the effects pregnancy has on various rheumatic diseases and the effects these diseases have on pregnancy, as well as providing advice regarding the alteration and monitoring of therapy before, during and after pregnancy.
Keyphrases
- preterm birth
- end stage renal disease
- pregnancy outcomes
- ejection fraction
- chronic kidney disease
- rheumatoid arthritis
- newly diagnosed
- prognostic factors
- pregnant women
- preterm infants
- peritoneal dialysis
- stem cells
- oxidative stress
- mesenchymal stem cells
- patient reported outcomes
- palliative care
- bone marrow
- cancer therapy
- rheumatoid arthritis patients