SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma.

Brianna R DaleyNancy E SealoverErin SheffelsJacob HughesDaniel GerlachMarco H HofmannKaja KostyrokoBarbara MairAmanda LinkeZaria BeckleyAndrew FrankCliffton L Dalgard Robert L Kortum

Published in: bioRxiv : the preprint server for biology (2023)

inhibitors in lung adenocarcinoma cells.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell proliferation