Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice.
Iara Pérez-TaboadaSamuel AlberquillaEduardo D MartínRishi AnandStefania Vietti-MichelinaNchimunya N TebekaJames CantleyStephanie J CraggRosario MoratallaMario VallejoPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
Our results indicate that diabetes promotes striatal oxidative stress, alters dopamine neurotransmission, and increases vulnerability to neurodegenerative damage leading to motor impairment. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- oxidative stress
- type diabetes
- cardiovascular disease
- glycemic control
- uric acid
- climate change
- parkinson disease
- high fat diet induced
- functional connectivity
- randomized controlled trial
- prefrontal cortex
- ischemia reperfusion injury
- induced apoptosis
- adipose tissue
- systematic review
- insulin resistance
- metabolic syndrome
- skeletal muscle
- signaling pathway
- endoplasmic reticulum stress
- meta analyses