Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function.
Kenneth A DietzeKiet NguyenAashli PathniFrank FazekasJillian M BakerEtse GebruAlexander WangWenxiang SunEthan RosatiDavid LumAaron P RapoportXiaoxuan FanDjordje AtanackovicArpita UpadhayayaTim LuetkensPublished in: bioRxiv : the preprint server for biology (2024)
CAR-mediated trogocytosis directly causes CAR T cell exhaustion and fratricide but can be prevented by inhibiting the cysteine protease cathepsin B through overexpression of human cystatins.