Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion.

Wei WangTao TanQing CaoFreddy ZhangBenjamin ReinWei-Ming DuanZhen Yan

Published in: The international journal of neuropsychopharmacology (2022)

Our results suggest that HDAC inhibition provides a highly effective therapeutic strategy for behavioral deficits and excitation/inhibition imbalance in 16p11del/+ mice, likely via normalization of synaptic function in the PFC.

Keyphrases

histone deacetylase
mouse model
traumatic brain injury
type diabetes
metabolic syndrome
high fat diet induced
quantum dots