Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent Models.
Paulo César Trindade da CostaFrancisca Nayara D D MenezesDiego Cabral LacerdaJosé Patrocínio Ribeiro Cruz NetoLudmilla Christine Silva de SalesCristiane Cosmo Silva LuisPaula Brielle PontesMarinaldo Pacífico Cavalcanti NetoJosé Luiz de Brito AlvesPublished in: Foods (Basel, Switzerland) (2022)
Quercetin supplementation during pregnancy and lactation has been linked to a lower risk of maternal cardio-metabolic disorders such as gestational diabetes mellitus (GDM), dyslipidemia, preeclampsia, attenuation of malnutrition-related conditions, and gestational obesity in animal studies. Pre-clinical studies have shown that maternal supplementation with quercetin reduces cardio-metabolic diseases in dams and rodents' offspring, emphasizing its role in modifying phenotypic plasticity. In this sense, it could be inferred that quercetin administration during pregnancy and lactation is a viable strategy for changing cardio-metabolic parameters throughout life. Epigenetic mechanisms affecting the AMP-activated protein kinase (AMPK), nuclear factor-kappa B (NF-κB), and phosphoinositide 3-kinase (PI3 K) pathways could be associated with these changes. To highlight these discoveries, this review outlines the understanding from animal studies investigations about quercetin supplementation and its capacity to prevent or decrease maternal and offspring cardio-metabolic illnesses and associated comorbidities.
Keyphrases
- nuclear factor
- pregnancy outcomes
- protein kinase
- birth weight
- pregnant women
- toll like receptor
- weight gain
- gene expression
- metabolic syndrome
- human milk
- dairy cows
- lps induced
- oxidative stress
- skeletal muscle
- body mass index
- physical activity
- early onset
- preterm infants
- adipose tissue
- cell proliferation
- inflammatory response
- gestational age
- high fat diet induced