The association between HER2-low expression and prognosis of breast cancer: a systematic review and meta-analysis.

Yuyao TangGuoshuang ShenYuanfang XinZhoujuan LiYonghui ZhengMiaozhou WangZhen LiuYi ZhaoFuxing ZhaoDengfeng RenJiuda Zhao

Published in: Therapeutic advances in medical oncology (2023)

Compared to patients with HER2-zero BC, those with HER2-low BC had better OS in the overall population and hormone receptor-positive population, DFS in hormone receptor-positive population and lower pCR in the overall population. The biological differences between HER2-low and HER2-zero BCs, particularly in hormone receptor-positive patients, and the relationship between HER2-low expression status and prognosis need to be explored further.

Keyphrases

poor prognosis
end stage renal disease
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
binding protein