Drug delivery of 6-bromoindirubin-3'-glycerol-oxime ether employing poly(D,L-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solvents.
Anna CzapkaChristian GrunePatrick SchädelVivien BachmannKarl ScheuerMichael DiraufChristine WeberAlexios-Leandros SkaltsounisKlaus D JandtUlrich S SchubertDagmar FischerOliver WerzPublished in: Journal of nanobiotechnology (2022)
Our formulation method of PLGA-based nanoparticles by applying sustainable, non-toxic solvents is a feasible nanotechnology that circumvents the poor bioavailability and biocompatibility of the cargo 6BIGOE. This technology yields favorable drug delivery systems for efficient interference with inflammatory processes, with improved pharmacotherapeutic potential.