APOE effects on regional tau in preclinical Alzheimer's disease.

Christina B YoungEmily JohnsGabriel KennedyMichael E BelloyPhilip S InselMichael D GreiciusReisa A SperlingKeith A JohnsonKathleen L PostonElizabeth C Morminonull nullnull null

Published in: Molecular neurodegeneration (2023)

APOE influences early regional tau PET burden, above and beyond effects related to cross-sectional amyloid PET burden. Therapeutic strategies targeting underlying mechanisms related to APOE may modify tau accumulation among Aβ+ individuals.

Keyphrases

cognitive decline
high fat diet
cross sectional
cerebrospinal fluid
pet ct
computed tomography
positron emission tomography
mild cognitive impairment
pet imaging
risk factors
stem cells
adipose tissue
cancer therapy
drug delivery
insulin resistance
mesenchymal stem cells