NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.
Tianyi WangArne P NeyrinckPeng LiYan DingJiping TangGang ChenJohn H ZhangPublished in: Journal of neuroinflammation (2020)
These data showed that rh-NT-4 reduced the expression levels of pro-inflammatory cytokines, improved neurological function, attenuated neuroinflammation, and thereby mitigated post-hemorrhagic hydrocephalus after GMH by TrkB/PI3K/Akt/FoxO1 pathway. These results indicated that rh-NT-4 could be a promising therapeutic strategy to ameliorate neuroinflammation and hydrocephalus after GMH or other similar brain injuries.
Keyphrases
- pi k akt
- cerebral ischemia
- subarachnoid hemorrhage
- signaling pathway
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- brain injury
- cell proliferation
- cell cycle arrest
- cognitive impairment
- cerebrospinal fluid
- poor prognosis
- blood brain barrier
- inflammatory response
- transcription factor
- electronic health record
- big data
- white matter
- resting state
- anti inflammatory
- binding protein
- machine learning