Pepsin Digest of Gliadin Forms Spontaneously Amyloid-Like Nanostructures Influencing the Expression of Selected Pro-Inflammatory, Chemoattractant, and Apoptotic Genes in Caco-2 Cells: Implications for Gluten-Related Disorders.
Maria Georgina HerreraFrancesco NicolettiMarion GrasPhilipp W DörflerNicolo TonaliYvonne HannappelInga EnnenAndreas HüttenThomas HellwegKaren M LammersVeronica Isabel DoderoPublished in: Molecular nutrition & food research (2021)
This work demonstrates that p-gliadin is interfacial active, forming spontaneously amyloid-type structures that trigger genes in the Caco-2 cell line involved in recruiting specialized immune cells.
Keyphrases
- celiac disease
- genome wide
- induced apoptosis
- cell death
- cell cycle arrest
- poor prognosis
- bioinformatics analysis
- genome wide identification
- high resolution
- genome wide analysis
- molecular dynamics simulations
- dna methylation
- oxidative stress
- gene expression
- anti inflammatory
- signaling pathway
- binding protein
- irritable bowel syndrome