Analysis of BAFF gene polymorphisms in UK Graves' disease patients.

Laura Claire LaneKathleen R AllinsonKaty CampbellIshita BhatnagarLorna IngoeSalman RazviTim CheethamHeather J CordellSimon H PearceAnna L Mitchell

Published in: Clinical endocrinology (2018)

Dysfunction of the humoral immune system is an obligatory pathophysiological component of Graves' disease, hence BAFF is an excellent functional candidate gene. We have demonstrated, for the first time, a significant association of the BAFF polymorphism rs4000607 with Graves' disease in a UK cohort. Further work to elucidate the role of BAFF in the pathogenesis of Graves' disease is now warranted.

Keyphrases

immune response
ejection fraction
oxidative stress
gene expression
genome wide
cross sectional
dna methylation
chronic kidney disease