Plasticity of intestinal gene expression profile signatures reflected by nutritional interventions in piglets.
Dirkjan SchokkerIna HulseggeHenri WoeldersJohanna M J RebelPublished in: BMC genomics (2019)
We showed that it is possible to re-use (publicly available) transcriptomics data and produce temporal gene expression profiles for control piglets with overexpression of genes representing specific biological processes. Subsequently, by superimposing gene expression data from (nutritional) intervention studies we observed deviations from some of these reference profile(s) and thus the plasticity of the system. By employing this meta-analysis approach we highlighted the importance of birth and weaning and the underlying biological processes.
Keyphrases
- gene expression
- genome wide
- dna methylation
- systematic review
- electronic health record
- case control
- randomized controlled trial
- genome wide identification
- big data
- cell proliferation
- meta analyses
- single cell
- copy number
- mechanical ventilation
- transcription factor
- physical activity
- data analysis
- gestational age
- pregnant women