Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis.
Hsu-Wen TsengTibor T GlantMatthew A BrownTony J KennaGethin P ThomasAllison R PettitPublished in: BMC musculoskeletal disorders (2017)
Early intervention with anti-inflammatory treatment not only improved inflammatory symptoms but also ameliorated structural damage of spine in PGISp mice. This preclinical observation suggests that early anti-inflammatory intervention may slow radiographic progression in AS patients.
Keyphrases
- anti inflammatory
- ankylosing spondylitis
- randomized controlled trial
- mouse model
- end stage renal disease
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- disease activity
- stem cells
- systemic lupus erythematosus
- cell therapy
- adipose tissue
- physical activity
- patient reported outcomes
- drug induced
- replacement therapy