Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson's disease.

Jenny CeccariniCindy CasteelsRawaha AhmadMelissa CrabbéLaura Van de VlietHeleen VanhauteMathieu VandenbulckeWim VandenbergheKoen Van Laere

Published in: European journal of nuclear medicine and molecular imaging (2019)

Decreased CB1R availability in the prefrontal and midcingulate cortex in PD patients is strongly correlated with disturbances in executive functioning, episodic memory, and visuospatial functioning. Further investigation of regional CB1R expression in groups of PD patients with mild cognitive impairment or dementia is warranted in order to further investigate the role of CB1R expression in different levels of cognitive impairment in PD.

Keyphrases

mild cognitive impairment
working memory
cognitive impairment
cognitive decline
poor prognosis
end stage renal disease
ejection fraction
chronic kidney disease
functional connectivity
newly diagnosed
prognostic factors
long non coding rna
patient reported outcomes