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Recent advances in dynamic m6A RNA modification.

Guangchao CaoHua-Bing LiZhinan YinRichard A Flavell
Published in: Open biology (2016)
The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m(6)A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the 'writers', 'erasers' and 'readers' of m(6)A RNA modification. Moreover, we emphasize recent advances of biological functions of m(6)A and conceive the possible roles of m(6)A in the regulation of immune response and related diseases.
Keyphrases
  • immune response
  • gene expression
  • high throughput sequencing
  • rna seq
  • single cell
  • genome wide
  • dna methylation
  • dendritic cells
  • toll like receptor