Magnetic nanocomplexes for gene delivery applications.
Rih-Yang HuangZhuo-Hao LiuWei-Han WengChien-Wen ChangPublished in: Journal of materials chemistry. B (2021)
Gene delivery is an indispensable technique for various biomedical applications such as gene therapy, stem cell engineering and gene editing. Recently, magnetic nanoparticles (MNPs) have received increasing attention for their use in promoting gene delivery efficiency. Under magnetic attraction, gene delivery efficiency using viral or nonviral gene carriers could be universally enhanced. Besides, magnetic nanoparticles could be utilized in magnetic resonance imaging or magnetic hyperthermia therapy, providing extra theranostic opportunities. In this review, recent research integrating MNPs with a viral or nonviral gene vector is summarized from both technical and application perspectives. Applications of MNPs in cutting-edge research technologies, such as biomimetic cell membrane nano-gene carriers, exosome-based gene delivery, cell-based drug delivery systems or CRISPR/Cas9 gene editing, are also discussed.
Keyphrases
- magnetic nanoparticles
- gene therapy
- crispr cas
- magnetic resonance imaging
- stem cells
- copy number
- genome wide
- molecularly imprinted
- sars cov
- genome wide identification
- genome editing
- cell therapy
- single cell
- photodynamic therapy
- dna methylation
- genome wide analysis
- gene expression
- smoking cessation
- contrast enhanced
- tissue engineering
- tandem mass spectrometry
- iron oxide