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Role of cathepsin S In periodontal wound healing-an in vitro study on human PDL cells.

Svenja MemmertMarjan NokhbehsaimAnna DamanakiAndressa V B NogueiraAlexandra K PapadopoulouChristina PiperiEfthimia K BasdraBirgit Rath-DeschnerWerner GötzJoni A CirelliAndreas JägerJames Deschner
Published in: BMC oral health (2018)
Our findings provide original evidence that cathepsin S stimulates PDL cell proliferation and migration and, thereby, wound closure, suggesting that this cysteine protease might play a critical role in periodontal remodeling and healing. In addition, cathepsins might be exploited by periodontal bacteria to regulate critical PDL cell functions.
Keyphrases
  • wound healing
  • single cell
  • endothelial cells
  • induced apoptosis
  • stem cells
  • cell cycle arrest
  • mesenchymal stem cells
  • cell death
  • cell proliferation
  • pluripotent stem cells
  • single molecule