The Effects of Green Tea Catechins in Hematological Malignancies.
Fernanda Isabel Della ViaMarisa Claudia AlvarezRosanna Tarkany BastingSara Teresinha Olalla SaadPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
Green tea catechins are bioactive polyphenol compounds which have attracted significant attention for their diverse biological activities and potential health benefits. Notably, epigallocatechin-3-gallate (EGCG) has emerged as a potent apoptosis inducer through mechanisms involving caspase activation, modulation of Bcl-2 family proteins, disruption of survival signaling pathways and by regulating the redox balance, inducing oxidative stress. Furthermore, emerging evidence suggests that green tea catechins can modulate epigenetic alterations, including DNA methylation and histone modifications. In addition to their apoptotic actions, ROS signaling effects and reversal of epigenetic alterations, green tea catechins have shown promising results in promoting the differentiation of leukemia cells. This review highlights the comprehensive actions of green tea catechins and provides valuable insights from clinical trials investigating the therapeutic potential of green tea catechins in leukemia treatment. Understanding these multifaceted mechanisms and the outcomes of clinical trials may pave the way for the development of innovative strategies and the integration of green tea catechins into clinical practice for improving leukemia patient outcomes.
Keyphrases
- dna methylation
- clinical trial
- cell death
- induced apoptosis
- oxidative stress
- cell cycle arrest
- acute myeloid leukemia
- bone marrow
- gene expression
- signaling pathway
- clinical practice
- endoplasmic reticulum stress
- genome wide
- dna damage
- public health
- healthcare
- mental health
- pi k akt
- type diabetes
- randomized controlled trial
- anti inflammatory
- skeletal muscle
- human health
- adipose tissue
- metabolic syndrome
- weight loss
- ischemia reperfusion injury
- free survival
- risk assessment
- heat shock