Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation.

Omar Y MousaBrian D JuranBryan M McCauleyMette N VesterhusTrine FolseraasColeman T TurgeonAhmad Hassan AliErik M SchlichtElizabeth J AtkinsonChang HuDenise HarnoisElizabeth J CareyAndrea A GossardDevin OglesbeeJohn E EatonNicholas F LaRussoGregory J GoresTom H KarlsenKonstantinos N Lazaridis

Published in: Hepatology (Baltimore, Md.) (2021)

Patients with PSC demonstrated alterations of plasma BA consistent with known mechanisms of cholestasis, UDCA treatment, and IBD. Notably, BA profiles predicted future HD, establishing the clinical potential of BA profiling, which may be suited for use in clinical trials.

Keyphrases

clinical trial
ulcerative colitis
current status
single cell
randomized controlled trial
combination therapy
drug induced
phase ii
risk assessment
climate change