Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components.
Benedikt Hermann SieglerFlorian UhleChristoph LichtensternChristoph ArensMarek BartkuhnMarkus Alexander WeigandSebastian WeitererPublished in: PloS one (2018)
Our experiments demonstrate for the first time that differential CTCF binding at XL9 is accompanied by uncoupled MHC-II expression as well as transcriptional and epigenetic alterations of the MHC-II regulator CIITA in septic patients. Overall, our findings indicate a sepsis-induced enhancer blockade mediated by variation of CTCF at the intergenic sequence XL9 in altered monocytes during immunosuppression.
Keyphrases
- transcription factor
- acute kidney injury
- endothelial cells
- binding protein
- gene expression
- end stage renal disease
- intensive care unit
- ejection fraction
- dendritic cells
- dna methylation
- chronic kidney disease
- septic shock
- poor prognosis
- dna binding
- high glucose
- peripheral blood
- prognostic factors
- diabetic rats
- patient reported outcomes
- patient reported