Novel Nanohydroxyapatite (nHAp)-Based Scaffold Doped with Iron Oxide Nanoparticles (IO), Functionalized with Small Non-Coding RNA (miR-21/124) Modulates Expression of Runt-Related Transcriptional Factor 2 and Osteopontin, Promoting Regeneration of Osteoporotic Bone in Bilateral Cranial Defects in a Senescence-Accelerated Mouse Model (SAM/P6). PART 2.
Krzysztof MaryczAgnieszka SmieszekKatarzyna Kornicka-GarbowskaAriadna PielokMaciej JaneczekAnna LipińskaAnna NikodemJarosław FilipiakPaulina SobierajskaJean-Marie NedelecRafał Jakub WigluszPublished in: International journal of nanomedicine (2021)
This study demonstrates that the novel nanocomposite nHAp/IO can serve as a platform for therapeutic miRNA delivery. Obtained nanocomposite elicit pro-osteogenic signals, decreasing osteoclasts differentiation, simultaneously improving osteoblasts metabolism and their transition toward pre-osteocytes and bone mineralisation. The proposed scaffold can be an effective interface for in situ regeneration of osteoporotic bone, especially in elderly patients.
Keyphrases
- bone mineral density
- quantum dots
- postmenopausal women
- bone loss
- stem cells
- mouse model
- iron oxide nanoparticles
- body composition
- transcription factor
- soft tissue
- long non coding rna
- poor prognosis
- mesenchymal stem cells
- highly efficient
- cell proliferation
- bone marrow
- high throughput
- dna damage
- gene expression
- endothelial cells
- tissue engineering
- oxidative stress
- solid phase extraction
- binding protein
- nucleic acid