A Th1/IFNγ Gene Signature Is Prognostic in the Adjuvant Setting of Resectable High-Risk Melanoma but Not in Non-Small Cell Lung Cancer.
Benjamin DizierAndrea CallegaroMuriel DeboisBrigitte DrenoPeter HerseyHelen J GogasJohn M KirkwoodJohan Filip VansteenkisteLecia V SequistDjordje AtanackovicJelle GoemanHans van HouwelingenSusana SalcedaFawn WangPatrick TherasseChanna DebruyneBart SpiessensVincent G BrichardJamila LouahedFernando Ulloa-MontoyaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
These findings provide evidence that expression of Th1/IFNγ genes in the TME, as measured by this GS, is associated with clinical outcome in melanoma. This suggests that, using this GS, patients with stage IIIB/C melanoma can be classified into different risk groups.