Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation.

Hailan ZhaoYoulian ZhouJing XuYong ZhangHong WangChong ZhaoHongli HuangJing YangChen HuangYingfei LiLisheng WangYu Qiang Nie

Published in: Journal of translational medicine (2024)

Our approach provides new opportunities to rationally harness live gut probiotic strains and metabolites to reduce intestinal inflammation, restore gut microbial composition, and expedite the development of safe and effective treatments for IBD.

Keyphrases

ulcerative colitis
fatty acid
escherichia coli
oxidative stress
ms ms
microbial community
transcription factor
signaling pathway
pi k akt