Unravelling Robust Brain-Behavior Links of Depressive Symptoms Through Granular Network Models: Understanding Heterogeneity and Clinical Implications.
René FreichelAgatha LenartowiczLinda DouwJohann D KruschwitzTobias BanaschewskiGareth J BarkerArun L W BokdeSylvane DesrivièresHerta FlorAntoine GrigisHugh GaravanAndreas HeinzRüdiger BrühlJean-Luc MartinotMarie-Laure Paillère MartinotEric ArtigesFrauke NeesDimitri Papadopoulos OrfanosTomáš PausLuise PoustkaNathalie HolzChristian BaeuchlMichael N SmolkaNilakshi VaidyaRobert WhelanVincent FrouinGunter Schumannnull nullHenrik WalterTessa F BlankenPublished in: medRxiv : the preprint server for health sciences (2023)
This study showcases the utility of network models in parsing heterogeneity in depressive symptoms, linking individual symptoms to specific neural substrates. We outline the next steps to integrate neurobiological and cognitive markers to unravel MDD's phenotypic heterogeneity.