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Photo- and Cu-Mediated 11 C Cyanation of (Hetero)Aryl Thianthrenium Salts.

Kevin ChengE William WebbGregory David BowdenJay S WrightXia ShaoMelanie S SanfordPeter J H Scott
Published in: Organic letters (2024)
We present a photo- and Cu-mediated 11 C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.
Keyphrases
  • ionic liquid
  • randomized controlled trial
  • machine learning
  • deep learning
  • aqueous solution
  • electron transfer