Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells.

Xiao XiaoRaj PutatundaYonggang ZhangPriya V SoniFang LiTing ZhangMingyang XinJin Jun LuoJohn R BetheaYuan ChengWenhui Hu

Published in: Journal of neuroinflammation (2018)

This study provides the first evidence for the expression and function of LTβR signaling in NSCs/NPCs. Activation of LTβR signaling promotes glial lineage differentiation. Our results suggest that neurogenesis is regulated by the adaptive immunity and inflammatory responses.

Keyphrases

single cell
poor prognosis
signaling pathway
neuropathic pain
oxidative stress
spinal cord injury
immune response
cell fate
cell proliferation
pi k akt
binding protein