Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.
Xiaoqiang YangHonghui ZengLe WangSiweier LuoYiming ZhouPublished in: Cell & bioscience (2022)
In summary, these results revealed that activation of Piezo1 could downregulate the renin expression in JG cells and mice, subsequently a reduction of blood pressure, highlighting its therapeutic potential as a drug target of the renin-angiotensin system.
Keyphrases
- blood pressure
- induced apoptosis
- cell cycle arrest
- poor prognosis
- hypertensive patients
- heart rate
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- cell death
- adipose tissue
- type diabetes
- emergency department
- metabolic syndrome
- skeletal muscle
- angiotensin converting enzyme
- high fat diet induced
- cell proliferation
- electronic health record
- binding protein
- adverse drug
- wild type