Related expression of TRKA and P75 receptors and the changing copy number of MYC-oncogenes determine the sensitivity of brain tumor cells to the treatment of the nerve growth factor in combination with cisplatin and temozolomide.
Alexander N ChernovDiana A AlaverdianOleg S GlotovMichael V TalabaevStanislav P UrazovSergei G ShcherbakAlessandra RenieriElisa FrullantiOlga ShamovaPublished in: Drug metabolism and personalized therapy (2020)
The relative expression of NGF receptors (TrkA/p75) and its correlation with CI of NGF and its combinations in AA and GB cells point to the mechanism involving a cell death signaling pathway. NGF downregulates (p<0.05) some increased copy numbers of MYCC and MYCN in the human MB cell cultures, and upregulates normal two copies of both oncogenes (p<0.05).
Keyphrases
- growth factor
- copy number
- cell death
- poor prognosis
- induced apoptosis
- mitochondrial dna
- signaling pathway
- cell cycle arrest
- endothelial cells
- genome wide
- pi k akt
- single cell
- dna methylation
- binding protein
- epithelial mesenchymal transition
- oxidative stress
- induced pluripotent stem cells
- long non coding rna
- white matter
- newly diagnosed
- endoplasmic reticulum stress
- resting state
- functional connectivity
- mesenchymal stem cells
- brain injury
- cerebral ischemia
- bone marrow