Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain.

José Osvaldo Barbosa NetoJoão Batista Santos GarciaMaria do Socorro de Souza CartágenesAndressa Godoy AmaralLuiz Fernando OnuchicHazem Adel Ashmawi

Published in: Journal of translational medicine (2019)

Our data suggest an antinociceptive effect of androgens following plantar incision. The expression of genes that encode voltage-gated sodium channels was not influenced by androgen blockade.

Keyphrases

postoperative pain
poor prognosis
genome wide
chronic pain
binding protein
pain management
genome wide identification
big data
neuropathic pain
gene expression
dna methylation
spinal cord injury
genome wide analysis