Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children.

Bacterial culture significantly underestimates the burden of S. pyogenes in pyoderma, particularly when co-infected with S. aureus. Molecular methods should be used to enhance the detection of S. pyogenes in surveillance studies and clinical trials of preventative measures in RHD-endemic settings.