Differential DNA methylation profile in infants born small-for-gestational-age: association with markers of adiposity and insulin resistance from birth to age 24 months.
Marta DiazEdurne GardeAbel Lopez-BermejoFrancis de ZegherLourdes IbañezPublished in: BMJ open diabetes research & care (2021)
In conclusion, at 12 months, abnormal methylation of GPR120 and NKX6.1 persists and new epigenetic marks further involved in adipogenesis and energy homeostasis arise in SGA infants. These abnormalities may contribute to metabolic dysfunction and diabetes risk later in life.
Keyphrases
- gestational age
- dna methylation
- insulin resistance
- birth weight
- preterm birth
- genome wide
- type diabetes
- high fat diet induced
- gene expression
- glycemic control
- metabolic syndrome
- adipose tissue
- cardiovascular disease
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- oxidative stress
- copy number
- fatty acid
- low birth weight
- weight gain
- preterm infants
- body mass index