Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents.
Muhammad AyazSyed Wadood Ali ShahMohammad ShoaibFawad Ali ShahFawad AhmedPublished in: Future medicinal chemistry (2024)
Aim: To synthesize aurone (Ar) derivatives and to demonstrate their effects against diabetes mellitus (DM) and neurodegeneration. Materials & methods: Five Ar ( A-E ) derivatives were synthesized, characterized by proton NMR and screened for antioxidant, anti-diabetic and anti-cholinesterase activities. They were further evaluated for neuroprotective effects in streptozotocin (STZ)-induced neurodegenerative model. Results: Among the aurone derivatives ArE demonstrated significant reversal of cognitive impairment, oxidative stress and neuroinflammation. Biochemical analysis revealed anti-diabetic and neuroprotective effects, possibly through downregulation of inflammatory markers and upregulation of antioxidant enzymes. Conclusion: Synthesized Ar ( A-E ) exhibits promising therapeutic potential against STZ-induced neurodegeneration and DM by modulating inflammatory and oxidative pathways, suggesting a novel avenue for disease management.
Keyphrases
- diabetic rats
- oxidative stress
- cognitive impairment
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- signaling pathway
- type diabetes
- cell proliferation
- magnetic resonance
- glycemic control
- high resolution
- structure activity relationship
- wound healing
- traumatic brain injury
- lipopolysaccharide induced
- poor prognosis
- metabolic syndrome
- inflammatory response
- skeletal muscle
- endothelial cells
- mass spectrometry
- heat shock
- insulin resistance
- blood brain barrier
- brain injury
- single cell
- subarachnoid hemorrhage
- drug induced
- high fat diet
- anti inflammatory
- oxide nanoparticles