Inflammatory Bowel Disease in Children With Systemic Juvenile Idiopathic Arthritis.
Justine MallerEmily FoxK T ParkSarah Sertial PaulKevin W BaszisCharlotte BoroccoSampath PrahaladPierre Quartier Dit MaireAdam ReinhardtDieneke Schonenberg-MeinemaLauren Shipman-DuensingMaria Teresa de Sande E Lemos Ramos Ascensão TerreriJulia F SimardIdit LaviElizabeth ChalomJoyce HsuDevy ZismanElizabeth D Mellinsnull nullPublished in: The Journal of rheumatology (2020)
IBD in the setting of sJIA is a rare occurrence. The favorable response of sJIA symptoms to therapeutic TNF-α inhibition suggests that the sJIA-IBD cohort may represent a mechanistically distinct sJIA subgroup. Our study highlights the importance of maintaining a high level of suspicion for IBD when gastrointestinal involvement occurs in patients with sJIA and the likely broad benefit of TNF-α inhibition in those cases.