Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer.
Seyed PairawanKenneth R HessFilip JankuNora S SanchezKenna R Mills ShawCathy EngSenthilkumar DamodaranMilind JavleAhmed O KasebDavid S HongVivek SubbiahSiqing FuDavid R FogelmanVictoria M RaymondRichard B LanmanFunda Meric-BernstamPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Higher levels of cfDNA VAF and a higher number of NSMs were associated with worse OS in patients with metastatic disease. Further study is needed to determine optimal VAF thresholds for clinical decision making and the utility of cfDNA VAF as a prognostic marker in different tumor types.