Role of age, Rho-kinase 2 expression, and G protein-mediated signaling in the myogenic response in mouse small mesenteric arteries.

Karl BjörlingPhilomeena D JosephKristian EgebjergMax SalomonssonJakob L HansenTrine P LudvigsenLars Jørn Jensen

Published in: Physiological reports (2019)

MT development in SMAs occurs through a Gαq/11 /PLC/Ca2+ -dependent pathway, and is maintained via ROCK2-mediated Ca2+ sensitization. Increased MT at mature adulthood can be explained by increased ROCK2 expression/activity.

Keyphrases

poor prognosis
protein kinase
binding protein
skeletal muscle
tyrosine kinase
blood flow