Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles.

Randy B KangYansui LiCarolina RosselotTuo ZhangMustafa SiddiqPrashant RajbhandariAndrew F StewartDonald K ScottAdolfo Garcia-OcañaGeming Lu

Published in: Genome medicine (2023)

In summary, snRNA-seq and pre-mRNA analysis of human islet cells can accurately identify human islet cell populations, subpopulations, and their dynamic transcriptome profile in vivo.

Keyphrases

single cell
endothelial cells
genome wide
rna seq
induced pluripotent stem cells
pluripotent stem cells
dna methylation
induced apoptosis
stem cells
cell therapy
oxidative stress
endoplasmic reticulum stress