Hyperoside Inhibits RNF8-mediated Nuclear Translocation of β-catenin to Repress PD-L1 Expression and Prostate Cancer.
Jie ChenYi ZhaoXiaoli WangLong ZangDengke YinSong TanPublished in: Anti-cancer agents in medicinal chemistry (2024)
Hyperoside exerts its anti-PCa effect by reducing RNF8 protein, inhibiting nuclear translocation of β-catenin, and disrupting the Wnt/β-catenin pathway, in turn reducing the expression of PD-L1 and improving Jurkat cell immunity.
Keyphrases
- prostate cancer
- cell proliferation
- epithelial mesenchymal transition
- poor prognosis
- binding protein
- radical prostatectomy
- single cell
- signaling pathway
- dna damage response
- stem cells
- cell therapy
- fluorescent probe
- sensitive detection
- living cells
- amino acid
- dna damage
- long non coding rna
- mesenchymal stem cells
- small molecule